Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 540-545, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812083
Responsible library:
WPRO
ABSTRACT
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Staphylococcus aureus
/
Plant Extracts
/
Microbial Sensitivity Tests
/
Chemistry
/
Holarrhena
/
Alkaloids
/
Methicillin-Resistant Staphylococcus aureus
/
Anti-Bacterial Agents
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Document type:
Article