Megastigmane glucosides isolated from Dichrocephala benthamii / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 288-291, 2017.
Article
in En
| WPRIM
| ID: wpr-812113
Responsible library:
WPRO
ABSTRACT
The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside (compound 1), together with its four known analogues (compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses (UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method. Compound 5 showed weak activity against HepG-2, while the other compounds did not show remarkable inhibitory effects.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Drug Screening Assays, Antitumor
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
China
/
Asteraceae
/
Cyclohexanones
/
Norisoprenoids
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Document type:
Article