A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 139-141, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812297
Responsible library:
WPRO
ABSTRACT
AIM@#To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.@*METHOD@#Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.@*RESULTS@#A dimeric diarylheptanoid, named alpinin B (1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B (1), 1, 7-diphenyl-3,5-heptanedione (2), (4E)-1, 7-diphenylhept-4-en-3-one (3) and (4E)-7- (4-hydroxyphenyl)-1-phenylhept-4-en-3-one (4).@*CONCLUSION@#Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol·L(-1).
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Glioblastoma
/
Rhizome
/
Alpinia
/
Diarylheptanoids
/
Cell Line, Tumor
/
Therapeutic Uses
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Document type:
Article