New flavonoids and methylchromone isolated from the aerial parts of Baeckea frutescens and their inhibitory activities against cyclooxygenases-1 and -2 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 615-620, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812368
Responsible library:
WPRO
ABSTRACT
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5″-O-galloyl)-α-L-arabinofuranoside (1), 6-methylquercetin 7-O-β-D-glucopyranoside (2), one new methylchromone glycoside, 7-O-(4', 6'-digalloyl)-β-D-glucopyranosyl-5-hydroxy-2-methylchromone (3), together with three known compounds (4-6). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods. The anti-inflammatory activities of the compounds 1-6 were evaluated for their inhibitory effects against cyclooxygenases-1 and -2 in vitro. Compounds 1-6 showed potent COX-1 and COX-2 inhibiting activities in vitro with IC values ranging from 1.95 to 5.54 μmol·L and ranging from 1.01 to 2.27 μmol·L, respectively.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Flavonoids
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Cyclooxygenase Inhibitors
/
Myrtaceae
/
Plant Components, Aerial
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Cyclooxygenase 1
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Cyclooxygenase 2
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Anti-Inflammatory Agents
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article