Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 456-464, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812385
Responsible library:
WPRO
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drug Screening Assays, Antitumor
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Lipopolysaccharides
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Crystallography, X-Ray
/
HL-60 Cells
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Nuclear Magnetic Resonance, Biomolecular
/
Isodon
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article