Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 231-240, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812408
Responsible library:
WPRO
ABSTRACT
Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pain
/
Molecular Structure
/
Chemistry
/
Limonins
/
Drug Therapy
/
Edema
/
Drug Discovery
/
Analgesics
/
Anti-Inflammatory Agents
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article