Isolation and identification of two new compounds from marine-derived fungus Acremonium fusidioides RZ01 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 934-938, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812538
Responsible library:
WPRO
ABSTRACT
Two new compounds, (22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one (1) and fusidione (3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol (2) and microperfuranone (4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC values being16.6 and 44.9 μmol·L, respectively.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Seawater
/
Acremonium
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Classification
/
HL-60 Cells
/
Cell Proliferation
/
Fermentation
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Document type:
Article