Expressions of glutathione S-transferase P1 and 4- hydroxynonenal and the progression of prostate cancer / 中华男科学杂志
National Journal of Andrology
; (12): 412-416, 2017.
Article
in Zh
| WPRIM
| ID: wpr-812751
Responsible library:
WPRO
ABSTRACT
Objective@#To investigate the expressions of glutathione S-transferase (GSTP1) and tetra-hydroxynonenal (4-HNE) in prostate cancer (PCa) and their clinical significance.@*METHODS@#We determined the expressions of GSTP1 and 4-HNE in 40 patients with PCa and another 42 with benign prostatic hyperplasia (BPH) by immunohistochemistry and analyzed their relationship with Gleason grades.@*RESULTS@#The expression rate of GSTP1 was 92.9% in the BPH tissue, and those in the highly, moderately, and lowly differentiated PCa tissues were 58.3%, 20.0%, and 16.7%, respectively, significantly higher in the BPH than in the PCa group (P <0.01). However, the positive rate of 4-HNE was only 5.0% in the BPH tissue, markedly lower than 91.6%, 100.0%, and 100.0% in the highly, moderately, and lowly differentiated PCa tissues (P <0.01). There was a negative correlation between the expression of GSTP1 and that of 4-HNE in the PCa tissue (r = -2.73, P <0.01).@*CONCLUSIONS@#Expression deletion of GSTP1 and high expression of 4-HNE may play an important role in the progression of prostate cancer.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pathology
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Prostatic Hyperplasia
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Prostatic Neoplasms
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Immunohistochemistry
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Disease Progression
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Aldehydes
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Glutathione S-Transferase pi
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Neoplasm Grading
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Metabolism
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Neoplasm Proteins
Limits:
Humans
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Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2017
Document type:
Article