Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 241-245, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-813900
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia.@*METHODS@#Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia.@*RESULTS@#Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia.@*CONCLUSION@#The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Chromosome Deletion
/
Seminal Plasma Proteins
/
Chromosomes, Human, Y
/
Diagnosis
/
Azoospermia
/
Genetic Loci
/
Genetics
/
Infertility, Male
/
Karyotyping
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Document type:
Article