Non-alcoholic fatty liver, high sensitivity C reactive protein and insulin resistance / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 565-570, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-814037
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the relationship among non-acoholic fatty liver disease (NAFLD), high sensitivity reactive C protein (hsCRP) and insulin resistance.@*METHODS@#Workers of an enterprise in Changsha for health examination in Second Xiangya Hospital from October to December, 2006, NAFLD group (243 patients) and a control group without fatty liver disease (361 patients) were randomly drawn. Questionnaire, physical examination, fasting plasma glucose, serum lipid-profile, alanine aminotransferase (ALT),blood uric acid, and abdominal ultrasonographic examination were undertaken in the 2 groups.@*RESULTS@#The moderate NAFLD group had significantly higher hsCRP concentration and homeostasis model assessment of insulin resistance (HOMA-IR) as compared with the mild NAFLD group (P or = 1 mg/L). Compared with the low concentration group, the odds ratio of the high concentration group for prevalence of NAFLD was 5.937(P<0.001). Multi-factor logistic regression analysis demonstrated that NAFLD was independently correlated with hsCRP or HOMA-IR after adjustment for sex, age and metabolic components (OR=2.044, 7.896,P<0.01).@*CONCLUSION@#NAFLD is closely correlated with hsCRP and HOMA-IR. Insulin resistance and elevated hsCRP concentration are the independent risk factors for the presence of NAFLD.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
C-Reactive Protein
/
Insulin Resistance
/
China
/
Epidemiology
/
Regression Analysis
/
Risk Factors
/
Fatty Liver
/
Metabolism
Type of study:
Diagnostic study
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Etiology study
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Prognostic study
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Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Document type:
Article