Mouse model of experimental antoimmune encephalomyelitisin C57BL/6J and expression of macrophage migration inhibitory factor / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 931-936, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-814173
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To detect the expression of macrophage migration inhibitory factor(MIF) in the brain and spinal cord of chronic non-remitting model of experimental autoimmune encephalomyelitis(EAE) mouse, and to discuss their effect on EAE/MS.@*METHODS@#Seventy-two female SPF C57BL/6J mice, aged 6k8 weeks, were randomly divided into an EAE group, a blank group, and an adjuvant group. The mice were immuned by mMOG35-55 and CFA. Immunohistochemic technique was used to detect the expression of MIF in the brain and spinal cord.@*RESULTS@#In the EAE group, we observed up-regulation of MIF of central nervous system(CNS) at onset, peak and chronic phase. During each phase, the difference of MIF between the EAE group and each of the other 2 groups was significant (P<0.05). In the EAE group, the expression of MIF was the highest at the peak, which was different from other periods (P<0.05).@*CONCLUSION@#MIF significanty expressed during the procedure of EAE disease, and may be related with the onset and exacerbation of EAE.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Brain
/
Random Allocation
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Up-Regulation
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Macrophage Migration-Inhibitory Factors
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Disease Models, Animal
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Encephalomyelitis, Autoimmune, Experimental
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Metabolism
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Mice, Inbred C57BL
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Document type:
Article