Protective effect of aminophylline on cerebral injury during cardiopulmonary bypass in infants / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1126-1131, 2009.
Article
in Zh
| WPRIM
| ID: wpr-814184
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the protective effect of aminophylline on cerebral injury induced by cardiopulmonary bypass (CPB) in infants.@*METHODS@#Forty patients who underwent ventricular septal defect within 3 years old were randomly divided into 2 groups(20 cases in each group).Aminophylline group:aminophylline (5 mg/kg) was injected slowly via the vein after anesthesia and maintained at a dose of 0.5 mg/(kg.h) until the end of CPB.@*CONTROL GROUP@#aminophylline was replaced by Ringer's lactated solution. Samples were obtained at the beginning of CPB (T(1)),the end of CPB (T(2)),6 h (T(3)) and 24 h (T(4)) after the operation to measure S-100 beta protein, NSE, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and interleukin-10 (IL-10) concentration by ELISA in the 2 groups.@*RESULTS@#Compared with the time point immediately before CPB, the S-100beta protein,NSE, TNF-alpha, and IL-8 concentration in the 2 groups began to increase with the start of CPB, reached a climax at the end of CPB (T(2)),decreased gradually 6 h after the termination of CPB(T(3)) and could not restore to the level before CPB at T(4)(24 h after the termination of CPB).IL-10 in the 2 groups both increased after the CPB. At T(2) and T(3), S-100beta protein,NSE, TNF-alpha, and IL-8 concentrations were significantly lower than those in the aminophylline group (P<0.05 or P<0.01), while IL-10 was just the opposite.@*CONCLUSION@#There is cerebral damage induced by CPB. Aminophylline may play a protective role in cerebral injury by modulating the balance between the pro-inflammatory factor and anti-inflammatory factor to reduce the level of S-100beta protein and NSE during CPB and open cardiac surgeries.
Full text:
1
Database:
WPRIM
Main subject:
General Surgery
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Cardiovascular Surgical Procedures
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Blood
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Brain Diseases
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Cardiopulmonary Bypass
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S100 Proteins
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Neuroprotective Agents
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Therapeutic Uses
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Drug Therapy
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S100 Calcium Binding Protein beta Subunit
Limits:
Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Document type:
Article