Clinical characteristics of histoplamosis in 8 patients: case report and literature review / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 644-652, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-814985
Responsible library:
WPRO
ABSTRACT
To explore the clinical characteristics, imaging manifestation, diagnosis and treatment for histoplasmosis and to improve therapeutic level, we retrospectively analyzed the clinical data of 8 patients with biopsy-confirmed histoplasmosis from 2004 to 2014 in the Second Xiangya Hospital of Central South University and reviewed relevant literatures. The main clinical symptoms of histoplasmosis included fever, cough, expectoration, chest pain, blood-stained sputum, lymphadenectasis, etc. The major lung imaging features were mass, node or pneumonia-like performance. No case was diagnosed as histoplasimosis firstly. Four patients whose imaging manifestations were focal pulmonary lesion received lobectomy of lung lesions or wedge resection. Clinical and imaging manifestations in 3 patients, who treated with amphotericin B or its liposomal, itraconazole or fluconazole, were improved. The clinical symptoms and imaging findings of histoplasmosis are nonspecific. It is easy for the physicians to misdiagnose histoplasmosis as bacterial infection, lung cancer, tuberculosis lymphoma, etc. Therefore, it is significant and necessary to carry out multiple biopsies combined with multiple etiological examinations for patients with difficult diagnosis.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Sputum
/
Biopsy
/
Amphotericin B
/
Retrospective Studies
/
Diagnostic Errors
/
Histoplasmosis
/
Lung
/
Lung Neoplasms
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2016
Document type:
Article