Relation between mismatch repair genes and colon cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 190-194, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-815453
Responsible library:
WPRO
ABSTRACT
Mismatch repair (MMR) system is one form of DNA repair mechanisms, which plays an important role in rectifying the mismatch of base pairs, reducing gene mutations and keeping genome stability. Abnormal expression of MMR regulated by miRNA is closely related to the development of colon cancer. Functional defects of MMR (dMMR) with particular clinical characteristics can be used as a potential prognostic and predictive biomarker. This article reviews the relation between MMR system, miRNA and colon cancer.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Colonic Neoplasms
/
MicroRNAs
/
DNA Mismatch Repair
/
Genetics
/
Mutation
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Document type:
Article
