A retrospective study of pathological margin evaluation in breast-conserving surgery specimens of patients with early breast cancer / 中国实用外科杂志

ABSTRACT

OBJECTIVE: To explore the clinical value of pathological evaluation of incision margin of breast-conserving operation specimens for early breast cancer. METHODS: The clinical data of early breast cancer patients undergone breast-conserving surgery in the Breast Disease Center of the Peking University First Hospital from January 1,2013 to December 31,2017 were analyzed retrospectively. The consistency of intraoperative frozen pathology with postoperative paraffin pathology and the relationship between pathological margin and prognosis were discussed. RESULTS: A total of474 breast-conserving cases were included in the study. The overall recurrence and metastasis rate was 3.4%; the local recurrence rate(LRR)was 1.5%; the 5-year disease-free survival rate(DFS)was 95.7%,and the 5-year overall survival rate(OS)was 96.8%. The coincidence rate of paraffin pathology and intraoperative frozen pathology in evaluating the breast-conserving margin was 100%. There was no significant difference in local recurrence rate between positive and negative first margin(χ~2=1.371,P=0.242). There was no significant difference in disease-free survival rate and overall survival rate among patients with negative margin width(χ~2=0.123,P=0.726;χ~2=0.077,P=0.781),and no significant difference in local recurrence rate(χ~2=1.808,P=0.613). CONCLUSION: Rapid frozen pathological examination is safe and reliable in evaluating the incision margin of breast-conserving surgery. On the premise of the negative incision margin,there is no significant difference in disease-free survival rate and local recurrence rate among different incision margin widths.