Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
Endocrinology and Metabolism
; : 97-105, 2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-816624
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) at mid-pregnancy and postpartum glucose intolerance in women with gestational diabetes mellitus (GDM).METHODS:
We enrolled 348 pregnant women diagnosed with GDM from August 2012 to October 2016. We measured serum 25(OH)D levels at mid-pregnancy and carried out a 75-g oral glucose tolerance test at 6 to 12 weeks after delivery. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/mL.RESULTS:
The prevalence of vitamin D deficiency was 76.7% (n=267). Women with vitamin D deficiency had a higher prevalence of postpartum glucose intolerance than did those without vitamin D deficiency (48.7% vs. 32.1%, P=0.011). Serum 25(OH)D level was negatively correlated with hemoglobin A1c at antepartum and postpartum period (antepartum r=−0.186, P=0.001; postpartum r=−0.129, P=0.047). Homeostasis model assessment of β-cell function was positively correlated with serum 25(OH)D level only postpartum (r=0.138, P=0.035). The risk of postpartum glucose intolerance was 2.00 times (95% confidence interval, 1.13 to 3.55) higher in women with vitamin D deficiency than in those without vitamin D deficiency (P=0.018).CONCLUSION:
In women with GDM, vitamin D deficiency at mid-pregnancy is associated with an elevated risk of postpartum glucose intolerance.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Prevalence
/
Diabetes, Gestational
/
Glucose Intolerance
/
Pregnant Women
/
Postpartum Period
/
Glucose
/
Glucose Tolerance Test
Type of study:
Etiology study
/
Prevalence study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2020
Document type:
Article