Differential Effects of B/C Genotype Hepatitis B Virus on Hepatitis B Associated Nephritis in Different ALT States / 中山大学学报(医学科学版)

ABSTRACT

@#【Objective】To investigate the differential effects of B/C genotype hepatitis B virus on hepatitis B associat⁃ ed nephritis in different ALT states.【Methods】We retrospectively analysized 558 patients with hepatitis B virus associat⁃ ed glomerulonephritis in The First Hospital of Lanzhou University. All the selected patients have complete medical records and had undergone renal histopathology. Laboratory tests included：ALT，NAG，Cr，GFR，hepatitis B virus load and genotypes.【Results】We found genotype B and genotype C hepatitis B virus associated glomerulone nephritis was mainly diffuse membrane hypertrophic nephropathy（57.9% vs. 54.4%），followed by capillary hyperplastic glomerulonephritis （25.3% vs. 28.0%），and focal segment glomerulonephritis（9.7% vs. 9.0%）. Mesenteric hyperplastic lesions（7.1% vs. 8.6%）were rare. In the ALT normal group，B/C genotype hepatitis B virus had no differential effect on renal function （P > 0.05）. In the ALT ≥ double upper limit of normal group，blood creatinine，blood urea nitrogen，24 h urine protein quantification，urine N-acetyl- β-D-glucosidase，and urine β2 microglobulin significantly increased（P < 0.05）.Glomerular filtration rate significantly decreased（P < 0.05）in the genotype C hepatitis B-related glomerulonephritis group compared with the genotype B group. In the ALT normal group genotype B/C hepatitis B virus had no differential effect on the stage of chronic kidney disease（P > 0.05）. But in the ALT ≥ double upper limit of normal group，compared with genotype B，chronic kidney disease staging tends to be worse in the genotype C hepatitis B associated nephritis（χ 2 = 11.144，P = 0.025）.【Conclusion】Comparative analysis of the differential effects of different genotype hepatitis B virus on hepatitis B-associated nephritis will help to diagnose and treat hepatitis B-associated nephritis.