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Differential Effects of B/C Genotype Hepatitis B Virus on Hepatitis B Associated Nephritis in Different ALT States / 中山大学学报(医学科学版)
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-817766
Responsible library: WPRO
ABSTRACT
@#【Objective】To investigate the differential effects of B/C genotype hepatitis B virus on hepatitis B associat⁃ ed nephritis in different ALT states.【Methods】We retrospectively analysized 558 patients with hepatitis B virus associat⁃ ed glomerulonephritis in The First Hospital of Lanzhou University. All the selected patients have complete medical records and had undergone renal histopathology. Laboratory tests included:ALT,NAG,Cr,GFR,hepatitis B virus load and genotypes.【Results】We found genotype B and genotype C hepatitis B virus associated glomerulone nephritis was mainly diffuse membrane hypertrophic nephropathy(57.9% vs. 54.4%),followed by capillary hyperplastic glomerulonephritis (25.3% vs. 28.0%),and focal segment glomerulonephritis(9.7% vs. 9.0%). Mesenteric hyperplastic lesions(7.1% vs. 8.6%)were rare. In the ALT normal group,B/C genotype hepatitis B virus had no differential effect on renal function (P > 0.05). In the ALT ≥ double upper limit of normal group,blood creatinineblood urea nitrogen,24 h urine protein quantification,urine N-acetyl- β-D-glucosidase,and urine β2 microglobulin significantly increased(P < 0.05).Glomerular filtration rate significantly decreased(P < 0.05)in the genotype C hepatitis B-related glomerulonephritis group compared with the genotype B group. In the ALT normal group genotype B/C hepatitis B virus had no differential effect on the stage of chronic kidney disease(P > 0.05). But in the ALT ≥ double upper limit of normal group,compared with genotype B,chronic kidney disease staging tends to be worse in the genotype C hepatitis B associated nephritis(χ 2 = 11.144,P = 0.025).【Conclusion】Comparative analysis of the differential effects of different genotype hepatitis B virus on hepatitis B-associated nephritis will help to diagnose and treat hepatitis B-associated nephritis.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Sun Yat-sen University(Medical Sciences) Year: 2019 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Sun Yat-sen University(Medical Sciences) Year: 2019 Document type: Article
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