Role of metabolomics in precision drug therapy / 医学研究生学报

ABSTRACT

More and more evidence shows that metabolomics, as a mature research method of systems biology, is a comprehensive quantitative analysis of all small molecule metabolites of a biological system interacting with time and function. An insight into the disruption networks in disease by metabolomics technology is conducive to the discovery of new drugs, the elucidation of drug treatment mechanisms and the intervention of adverse reactions, which has brought about revolutionary changes in modern medical practice. This review describes the concepts, characteristics, research methods and key points of metabolomics, as well as its latest applications in pre-clinical and clinical fields, and expounds the roles of metabolomics in achieving "precision" and "cure" by exploring the genet-metabolite model.