Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat

ABSTRACT

OBJECTIVE@#To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat.@*METHODS@#MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined.@*RESULTS@#The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05).@*CONCLUSIONS@#These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.