A simple screening tool for non-alcoholic fatty liver disease based on healthy physical examination population / 公共卫生与预防医学

ABSTRACT

Objective To design a simple screening tool for non-alcoholic fatty liver disease based on Chinese healthy physical examination population. Methods Subjects were selected from the health management center of China Medical University since January 2017 to December 2017. A total of 32,578 subjects were included. 80% subjects were randomly selected as the training set for modeling and internal assessment, and the remaining 20% subjects were used as the verification set for external assessment. Stepwise logistic regression analysis was used to construct the NAFLD screening index. Results Multivariate regression analysis showed that body mass index (BMI), fasting glucose (FPG), serum triglyceride (TG), and aspartate aminotransferase/alanine aminotransferase (AST/ALT) were included in the NAFLD screening model. The constructed NAFLD screening index was 2×BMI+FPG+3×TG-7×(AST/ALT). The AUC of the index was 0.883 [95%CI (0.879, 0.887)] in the training set and was 0.888 [95%CI (0.880, 0.896)] in the verification set. Conclusion The NAFLD screening index, as a simple and effective screening tool, can be used to screen large-scale population at high risk, which has certain epidemiological and health economic significance.