Role of Shear Wave Elastography in Evaluating the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B
Gut and Liver
; : 852-859, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-82301
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).METHODS:
We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE.RESULTS:
The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (≥50 years) and higher LS value (≥10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (≥10 kPa) than in those with lower LS values ( < 10 kPa) (p=0.001).CONCLUSIONS:
Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
Incidence
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Carcinoma, Hepatocellular
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Hepatitis B, Chronic
/
Elasticity Imaging Techniques
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Hepatitis B
/
Hepatitis, Chronic
Type of study:
Diagnostic study
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Etiology study
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Incidence study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2017
Document type:
Article