Expression and clinical value of glycogen synthase kinase -3β, Dickkopf -1 and β-catenin in proximal gastric cancer / 中国基层医药

ABSTRACT

Objective To study the expression and clinical value of glycogen synthase kinase -3β(GSK-3β),Dickkopf -1(DKK-1) and β-catenin in patients with proximal gastriccancer.Methods FromApril2016 to April 2017,47 patients with proximal gastric cancer in Chengfeng Hospital of Daqing Oilfield Group were enrolled in this study.Immunohistological tests were performed in all patients'lesions,adjacent tissues and healthy tissues .The effects of different factors on the expression of GSK -3βandDKK-1 werecompared.Results Thepositive expression rate of GSK-3βin the normal tissues of patients with proximal gastric cancer was 70.21％(33/47),which was higher than those in the lesions and adjacent tissues [21.28％(10/47),21.28％(10/47)](χ2 =31.985,P<0.01). The positive expression rates of DKK -1 andβ-catenin in the gastric cancer tissues were 38.30％(18/47),82.98％(39/47),respectively,which were higher than those in the adjacent tissues and normal tissues [8.51％(4/47), 8.51％(4/47),and 6.38％(3/47),2.13％(1/47)](χ2 =20.517,88.471,all P<0.01).The GSK-3βpositive expression rate was higher in patients with tumor node metastasis ( TNM) stage I-II,moderately well differentiated , infiltrated more than 50％,non-metastatic lymph nodes (P<0.05).The DKK-1 positive expression rate was higher in patients with TNM stage III-IV,moderately well differentiated and less than 50％ infiltrated lymph nodes ( P<0.05).Conclusion GSK-3β,DKK-1 and β-catenin are important indicators in the development and metastasis of gastric cancer.The above indicators have clinical value in the diagnosis and evaluation of curative effect .