Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
; (4): 16-25, 2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-829023
Responsible library:
WPRO
ABSTRACT
The generation of induced pluripotent stem cells through somatic cell reprogramming requires a global reorganization of cellular functions. This reorganization occurs in a multi-phased manner and involves a gradual revision of both the epigenome and transcriptome. Recent studies have shown that the large-scale transcriptional changes observed during reprogramming also apply to long non-coding RNAs (lncRNAs), a type of traditionally neglected RNA species that are increasingly viewed as critical regulators of cellular function. Deeper understanding of lncRNAs in reprogramming may not only help to improve this process but also have implications for studying cell plasticity in other contexts, such as development, aging, and cancer. In this review, we summarize the current progress made in profiling and analyzing the role of lncRNAs in various phases of somatic cell reprogramming, with emphasis on the re-establishment of the pluripotency gene network and X chromosome reactivation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
English
Journal:
Genomics, Proteomics & Bioinformatics
Year:
2020
Document type:
Article