Research advances in high-risk factors for primary biliary cholangitis / 临床肝胆病杂志

ABSTRACT

Primary biliary cholangitis (PBC) is a multifactorial disease caused by the combined effect of genetic susceptibility and environmental triggers. Among the known risk factors for PBC, environmental factors mainly cause the onset of the disease by disrupting mitochondrial immune tolerance. With the deepening of research, especially the application of genome-wide association study technology, some dangerous genes have been found, such as human leukocyte antigen gene IL and X chromosome monomer. This article reviews the research advances in high-risk factors for PBC.