Protective effects of fenazinel dihydrochloride against stroke in stroke-prone spontaneously hypertensive rats / 第二军医大学学报

ABSTRACT

Objective To investigate the protective effect of fenasinel dihydrochloride (FD) against stroke in stroke-prone spontaneously hypertensive rats (SHRSP). Methods Seven-week old male SHRSP were fed with NaCl 1g/d to induce stroke. Meanwhile, FD was injected intraperitcmeally at 1, 3, and 10 mg/(kg • d). The stroke onset time, Survival period after stroke, and neuronic deficit score after stroke were observed. Results FD delayed the onset of stroke n SHRSP and prolonged the Survival of the animals. Furthermore, low and medium doses FD also improved the Neuronal deficit score after stroke. Conclusion Our data suggest that FD has protective effect in SHRSP.