Relationship between hypertension and osteoporosis in elderly female with type 2 diabetes mellitus / 第二军医大学学报

ABSTRACT

Objective: To investigate the relationship of hypertension with osteoporosis (OP) and bone mineral density (BMD) in elderly type 2 diabetic women. Methods: A total of 179 elderly type 2 diabetic women were categorized into hypertension group(n=124)and non-hypertension group(n=55). Lumbar and hip BMD were measured by dual-energy X-ray absorptiometry. Prevalences of osteoporosis were compared between the two groups using Chi-square test, and BMD was compared using covariance analysis. The correlation between the osteoporosis and risk factors was analyzed using binary logistic regression method. Results: The prevalences of osteoporosis (total OP, lumber OP and hip OP) in non-hypertension group were higher than that of the hypertension group(P1=0.037, P1=0.042 and Ph=0.051, respectively). Lumbar and hip BMD in the hypertension group was higher than that in the non-hypertension group, and there were significant differences in L3 and L4 BMDs between the two groups (P3=0.040, P4=0.021); however, the difference disappeared after adjustment for body mass index (BMD). After adjustment for C peptide, the P value also increased, but not as obvious as after adjustment for BMI. Binary logistic regression analysis showed that OP was associated with age, BMI and osteocalcin, but not with hypertension. Conclusion: OP is associated with the age, BMI, and osteocalcin, but not with hypertension in elderly type 2 diabetic women.