Mechanism of Wdpcp in regulating coronary artery development / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 361-363, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-843719
Responsible library:
WPRO
ABSTRACT
Wdpcp, a planar cell polarity (PCP) effector gene, plays essential roles in organogenesis during embryonic development through regulating collective cell movement and ciliogenesis. WDPCP mutations are associated with Bardet-Biedl syndrome and Meckel-Gruber syndrome in human. This study revealed a novel role of Wdpcp in regulating coronary artery development in mouse, demonstrating a new pathogenic phenotype associated with mutations of this gene in human. Results of this study may help us to understand the etiology of coronary artery disease.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Shanghai Jiaotong University(Medical Science)
Year:
2018
Document type:
Article