Determination of the content of rocuronium bromide by HPLC / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 127-129, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-845962
Responsible library:
WPRO
ABSTRACT
Objective:
To establish a HPLC method to determinate the content of rocuronium bromide.Methods:
NH2-bonding silica gel was used as the stationary phase. The mobile phase consisted of 0.04 mol/L tetramethyl ammonium hydroxide (pH adjusted to 7.4 by phosphoric acid) and acetonitrile (1090). The column temperature was 35°C. The detection wavelength was 207 nm.Results:
The relation between concentration and peak area was linear in the range of 0.1251-2.0065 mg/ml with r2 of 0.9999. The average recovery rate was 99.9% with RSD of 0.1%.Conclusion:
This method is exclusive, sensitive and is reliable for the determination of rocuronium bromide.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2010
Document type:
Article