Advances in chemoprevention of breast cancer / 肿瘤

ABSTRACT

Breast cancer is one of the most common malignant tumors in women, which seriously threatens the health of women. Estrogen promotes the development of breast cancer by binding to estrogen receptor and triggering a signaling cascade. The aromatase inhibitor (AI) and the selective estrogen receptor modulators (SERMs) prevent the effect of estrogenon promoting breast cancer through different mechanisms. Relevant studies have shown that SERMs and AI can effectively reduce the recurrence and metastasis of breast cancer, which suggests that they may effectively prevent the occurrence of breast cancer. The latest research progress in the randomized clinical trials of chemoprevention agents such as SERMs and AI are reviewed in this paper.