Clinicopathological characteristics and prognosis-related factors of gastric neuroendocrine carcinoma / 肿瘤

ABSTRACT

Objective: To investigate the clinicopathological characteristics and their relationship with the prognosis of gastric neuroendocrine carcinoma (G-NEC). Methods: Medical records of 46 patients with G-NEC between January 2009 and September 2015 were reviewed to investigate the clinicopathological characteristics and their relationship with prognosis of G-NEC. Results: Univariate analysis showed that the factors including age, Borrmann classification, TNM stage, M stage, Ki-67 index, surgical approach, liver metastases, serum carcino-embryonic antigen (CEA) level and postoperative chemotherapy were related with the prognosis of G-NEC (all P < 0.05). The multivariate analysis showed that the age, surgical approach, serum CEA level and postoperative chemotherapy were the independent prognostic factor of the prognosis (all P < 0.05). Conclusion: G-NEC is a rare tumor with high degree of malignancy and poor prognosis. Patients with high serum CEA level have poor prognosis, and postoperative chemotherapy and surgical outcomes also affect the prognosis of G-NEC.