Advances in research on ovarian cancer-related metastatic genes / 肿瘤

ABSTRACT

Ovarian cancer is the disease with a high mortality in gynecologic malignant tumors. Most patients had metastasis once diagnosed, and the invasion and metastasis are considered as the main reasons contributing to patients' death. The process of invasion and metastasis is complicated, involving multiple genes and steps which are related to diverse elements. In recent years, with the more and more research in the mechanism of tumor metastasis, it has found that a great deal of genes plays a significant role in invasion and metastasis of ovarian cancer. In this paper, it reviews the important advances about the role of enhancer of zeste homolog 2 (EZH2), matrix metalloproteinase-2 (MMP-2), metastasis-associated in colon cancer-1 (MACC1) and high mobility group A2 (HMGA2) in the invasion and metastasis of ovarian cancer.