The progress of microRNAs in early diagnosis and predictions of treatment efficacy and prognosis of pancreatic cancer / 肿瘤

ABSTRACT

Pancreatic cancer is of high malignance and poor prognosis, and it still lacks effective treatment currently. The main problems to be solved in the research of pancreatic cancer treatment are involved with low rate of diagnosis, high rate of drug resistance and high mortality. MicroRNAs (miRNAs) are a group of small, non-coding RNAs consisting of 19-24 nucleotides and may act as oncogenes and anti-oncogenes. MiRNAs play an important role in development, invasion, metastasis and drug resistance of pancreatic cancer, hence it may become a potential candidate of molecular biomarker for diagnosis and predictions of drug resistance and prognosis. More and more studies have demonstrated that miRNAs have a close relationship with pancreatic cancer, but the mechanism is still unclear. Further studies on the changes and specific functions of miRNAs in development and progression of pancreatic cancer will improve the understanding of the carcinogenesis of pancreatic cancer. Copyright © 2013 by TUMOR.