Expression of CIP2A in non-small cell lung cancer and its clinical significance / 肿瘤
Tumor
; (12): 942-945, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-849156
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the expression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in non-small cell lung cancer (NSCLC) tissues and its clinical significance.Methods:
The expressions of CIP2A protein in NSCLC tissues and their corresponding para-cancerous tissues from 97 cases of NSCLC were detected by immunohistochemistry. The relationship between the expression of CIP2A protein and the clinicopathological features in patients with NSCLC was analyzed.Results:
The positive expression rate of CIP2A protein in NSCLC tissues [76.3% (74/97)] was significantly higher than that in the corresponding para-cancerous tissues [5.2% (5/97)] (P 0.05). The overall survival time of patients with positive expression of CIP2A protein was shorter than that of patients with negative expression of CIP2A protein (P =0.001). The expression of CIP2A protein, TNM stage and the differentiation of tumor were independent prognostic factors of NSCLC (P <0.05).Conclusion:
The expression of CIP2A protein is significantly increased in NSCLC tissues, and the positive expression of CIP2A protein is associated with the prognosis of patients with NSCLC. Copyright© 2011 by TUMOR.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tumor
Year:
2011
Document type:
Article