Association of CCK and CCKAR gene polymorphisms with genetic susceptibilities of biliary tract cancer and cholelithiasis / 肿瘤

ABSTRACT

Objective: To investigate the relationship between the gene polymorphisms of cholecystokinin (CCK) and cholecystokinin A receptor (CCKAR) and genetic susceptibilities of biliary tract cancer and cholelithiasis in a Chinese population from Shanghai. Methods: A population-based case-control study was carried out in 253 cases of gallbladder cancer, 133 cases of extrahepatic bile duct cancer, 53 cases of cancer of Vater's ampulla, 440 cases of biliary stones, and 445 population controls. The genotypings of CCK rs747455 and CCKAR rs1800856 were performed by Real-time PCR. Results: Non-stone cases carrying the CCK rs747455 CT genotype reduced the risk of ampulla cancer, compared with the carriers of CC genotype [odds ratio (OR)=0.31, 95% confidence interval (CI)=0.10-0.96], and this association was still significant after Bonferroni correction (P=0.042). The drinkers who carrying TT or CT genotype increased the risk of cholelithiasis, compared with the carriers of CC genotype (OR=2.81, 95% CI=1.08-7.29; OR=2.93, 95% CI=1.03-8.33), but this association was not significant after Bonferroni correction (P=0.061). The genotyping of CCKAR rs1800856 was not associated with the risk of biliary tract cancer and cholelithiasis. Conclusion: CCK rs74745 gene polymorphism may be correlated to the susceptibilities of biliary tract cancer and cholelithiasis in a Chinese population form Shanghai, China. Copyright© 2011 by the Editorial Board of Tumor.