Effect of xiaozhong sanyu pills on brain edema in rats with intracerebral hemorrhage / 解放军医学杂志

ABSTRACT

Objective To observe the effect of Xiaozhong Sanyu pills (XZSY) on neurological severity score (NSS), brain water content and expression level of water channel aquaporin 4 (AQP4) in rats with intracerebral hemorrhage (ICH). Methods ICH model was reproduced by Rosenberg method in 150 SD rats, then the animals were randomly divided into model group (n=50), XZSY high dose group (n=50, 40 mg/kg of XZSY suspension was given by intragastric administration, bid) and XZSY low dose group (n=50, 20 mg/kg of XZSY suspension was given by intragastric administration, bid), and the latter two groups were further randomly divided into 12-h and 1-, 3-, 7-, and 10-d subgroups. The differences in NSS, brain water content and expression level of AQP4 among 3 groups were analyzed. Results Compared with control group, the NSS, brain water content and expression level of AQP4 were lowered at 3, 7 and 10 d in XZSY low dose group, and lowered at 1, 3, 7 and 10 d in XZSY high dose group (P<0.05, P<0.01). Compared with XZSY low dose group, the NSS and brain water content were lowered on 7 and 10 d, and expression level of AQP4 was lowered at 3, 7 and 10 d in XZSY high dose group (P<0.05, P<0.01). Conclusion Early administration of XZSY could reduce the expression of AQP4 after cerebral hemorrhage, and accordingly alleviate the intracellular edema and improve the prognosis of ICH.