Decreased Retinal Thickness in Patients With Alzheimer's Disease
Journal of the Korean Neurological Association
; : 173-177, 2013.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-85106
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
The loss of ganglion cells observed in Alzheimer's disease (AD) patients might be attributable to a neurodegenerative process involving the neuroretinal structure. The objective of this study was to determine the retinal thickness in patients with AD using optical coherence tomography (OCT).METHODS:
Neuro-ophthalmologic examinations were performed in eight AD patients and eight age-matched control subjects. The average thicknesses of the retinal nerve fiber layer (RNFL) and the ganglion cell-inner plexiform layer (GCIPL) were measured using spectral-domain OCT in both subject groups, and the results were compared.RESULTS:
The RNFL was thinner in AD patients than in the age-matched controls (p<0.05), especially at the nasal and inferior retina, and the GCIPL was also significantly thinner (p<0.05).CONCLUSIONS:
The decreased retinal thickness observed in AD patients suggests that OCT can be used as a biological marker of AD. The findings of this preliminary study suggest that the extent of the reduction in GCIPL and RNFL thicknesses should be investigated further.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Retina
/
Retinaldehyde
/
Biomarkers
/
Ganglion Cysts
/
Tomography, Optical Coherence
/
Alzheimer Disease
/
Nerve Fibers
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2013
Document type:
Article