A new sesquiterpenoid of agarwood from Aquilaria crassna / 中草药
Chinese Traditional and Herbal Drugs
; (24): 4480-4483, 2018.
Article
in Zh
| WPRIM
| ID: wpr-851645
Responsible library:
WPRO
ABSTRACT
Objective To study the chemical constituents of agarwood from Aquilaria crassna. Methods The compounds were isolated and purified by various column chromatographic techniques. Their structures were identified on the basis of spectral data and physicochemical properties. And the compounds were tested for α-glucosidase inhibitory activity by pNPG method. Results One new sesquiterpenoid along with two known chromones, which were determined as methyl crassicid (1), 8-chloro-6-hydroxy-2-(2- phenethyl) chromen-4-one (2), 8-chloro-6-hydroxy-2-[2-(4-methoxyphenyl) ethyl] chromen-4-one (3), were obtained from the ethyl acetate extract obtained from 95% ethanol extract of agarwood from A. crassna. Conclusion Compound 1 is a new sesquiterpenoid named sesquiterpenoid, which exhibited α-glucosidase inhibitory activity with IC50 value of 121.8 μg/mL.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2018
Document type:
Article