Optimization of processing technology of decoction pieces of Citri Reticulatae Pericarpium by Box-Behnken response surface methodology based on CRITIC-AHP weighted evaluation / 中草药

ABSTRACT

Objective To determine the weight coefficient and optimize the processing technology of decoction pieces of Citri Reticulatae Pericarpium (CRP). Methods The contents of narirutin, hesperidin, nobiletin, 3,5,6,7,8,3’,4’-heptamethoxy flavone (HF), and hesperetin were simultaneously determined by HPLC. The weight coefficient of each component was evaluated by CRITIC-AHP (analytic hierarchy process) methods. With composite score as index, Box-Behnken design-response surface methodology was adopted to investigate the effects of water addition, soaking time, and soaking temperature on the quality of the processed products and optimize the processing technology of decoction pieces of CRP. Results Optimal processing parameters were as follows 33% of water was added to 1 000 g of herbs, soaking time was 64 min, and soaking temperature was 45 ℃. Conclusion The optimized processing technology is simple and feasible, which can provide a reference for the processing of decoction pieces of CRP. The method established to simultaneously determine the contents of five components in decoction pieces of CRP is rapid and reliable for controlling the quality of decoction pieces of CRP.