Development of drug toxicity and novel strategy for toxicity of Chinese materia medica based on zebrafish model / 中草药

ABSTRACT

With the advantages of high throughput activity screening and toxicity evaluation, zebrafish has become popular model organism in pharmaceutical research in recent years. Being integrated advantages both in vivo and in vitro, with high efficiency and low cost, evaluation using zebrafish has become an effective method in quick screening of early safety of compounds on abroad. In past years, studies on toxicity of traditional Chinese medicine (TCM) with zebrafish model have attracted more attention in China. The development in drug toxicity studies based on zebrafish model was reviewed, and novel strategy for toxicity of TCM using zebrafish was suggested in the paper.