Triterpenoids from roots of Rosa laevigata / 中草药

ABSTRACT

Objective: To study the triterpenoids from the roots of Rosa laevigata. Methods: The silica gel column chromatography was used to extract and separate the chemical constituents from the roots of R. laevigata. HPLC was used to analyze its purity, chemical and spectroscopy methods were used to determine their structures. Results: Thirteen constituents were isolated and identified as niga-ichigosides F2 (1), rosamultin (2), arjunetin (3), kaji-ichigoside F1 (4), auscaphic acid (5), cecropiacic acid 3-methyl ester (6), 2-acetyl tormentic acid (7), pomolic acid (8), 2α,3α-dihydroxyurs-12,18-dien-28-oic acid (9), 3β-E-feruloyl corosolic acid (10), fupenzic acid (11), 2-O-acetyl euscaphic acid (12), and 12,13-dihydromicromeric acid (13). Conclusion: Compounds 3, 6, 7 and 9-13 are obtained from this plant for the first time. Compounds 10, 12 and 13 are obtained from the plants of Rosa L. for the first time.