Application of backward selection method based on Tujia medical trialistic theory in new drug research / 中草药

ABSTRACT

Based on the trialistic theory of drug properties, substances, and efficacy in Tujia medicine, We adopted the one-way thinking and research method from efficacy to substance or vice versa and utilized the multicomponent and multi-target advantage of traditional medicine. At last, we had developed the bidirectional or multidirectional thinking and research method from efficacy to efficacy or from substance to substance. In the study, we used the backward selection method based on the known effects of current drug to fine another new role with known efficacy related by analyzing components, so as to find new efficacy or safer usage; We used the known substances as a starting points to find the new chemicals with the function compared to the known efficacy, thus the drug processing will be guided and the new medicinal resources and drugs will be found. The backward selection method is a simple and effective research method, which might make better use of traditional medicinal components and advantages of drug multi-target, and promote the rational use of traditional medicine and the research and development of new drugs.