A new iridoid from Valeriana officinalis var. latiofolia / 中草药

ABSTRACT

Objective: To investigate the chemical constituents in the roots of Valeriana officinalis var. latiofolia collected from Guizhou province, China. Methods: The compounds 1-6 were separated and purified by column chromatography with silica gel, RP C18, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of spectroscopic (MS, NMR, etc) methods and chemical evidences. Results: Six compounds were isolated from ethyl acetate fractions of 95% ethanol extract of the root of V. officinalis var. latiofolia and identified as iridoids: valeriridoid P (1); dihydroxymaaliane (2), and madolin F (3); madolin A (4), volvalerenal B (5), and kissoone A (6), respectively. Conclusion: Compound 1 is a new iridoid with two oxo-bridges, and compounds 2-6 are known compounds.