Optimization of rutaecarpine solid lipid nanoparticles by central composite design and response surface methodology / 中草药
Chinese Traditional and Herbal Drugs
; (24): 1307-1313, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-854401
Responsible library:
WPRO
ABSTRACT
Objective:
To optimize the prescription of rutaecarpine solid lipid nanoparticles (Rut-SLN).Methods:
Using the film-ultrasound method to lining-up the Rut-SLN, with the entrapment efficiency (EE), Zeta potential, and the average particle size as the evaluation indexes, using central composite design to inspect the effects of glycerol monostearate/drug quality ratio (A), soybean lecithin for injection/glycerol monostearate mass ratio (B), Poloxamer 188 (C) on three factors of the EE, Zeta potential, and average particle size. Prediction and analysis for selecting the best prescription condition were carried out by using the response surface method.Results:
According to the optimized prescription, the EE, Zeta potential, and the average particle size of Rut-SLN was respectively 84.27%, 122.6 nm, and -20.7 mV.Conclusion:
The optimal prescription of Rut-SLN has better stability, feasibility, and high EE, which is suitable for the production.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Document type:
Article