Preparation of astragalus polvsaccharides-Eudragit S100 colon-specific spray drying powder and evaluation on its in vitro release / 中草药

ABSTRACT

Objective: To prepare the pH-dependent astragalus polvsaccharides colon-specific spray drying powder, with the intention of controlling drug release in the colon. Methods: Eudragit S100 water dispersion was used as a carrier to prepare astragalus polvsaccharides colon-specific spray drying powder by spray drying method and the in vitro dissolution of spray drying powder was performed. The structure characteristics of spray drying powder was analyzed by SEM. Results: When the ratio of drug to Eudragit S100 was 110, the drug in simulated gastric fluid did not release nearly and the accumulative drug-release percent in vitro at 4 h was less than 30.0%; But in the simulated colonic fluid, the accumulated drug release percent reached 90.0% within 1 h. Conclusion: The astragalus polysaccharides colon-specific spray drying powder had the characteristics as a colon-specific delivery system. The preparation process is simple and feasible.