Water-soluble constituents from Isodon lophanthoides var. gerardianus and their antitumor activities / 中草药
Chinese Traditional and Herbal Drugs
; (24): 3219-3223, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-854781
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the water-soluble constituents of Isodon lophanthoides var. gerardianus.Methods:
Compouds were isolated and purified by D-101, Sephadex LH-20, and ODS column chromatographies. The chemical structures were elucidated on the basis of spectral data and physicochemical properties.Results:
Twelve compounds were isolated and identified as vitexin II (1), vicenin III (2), isoschaftoside (3), schaftoside (4), vitexin (5), 6, 8-di-C-α-L-arabinosylapigenin (6), apigenin-7-O-glucuronide (7), apigenin 6-C-β-L-arabin-osyl-8-C-α-L-arabinopyranoside (8), apigenin 6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranoside (9), caffeic acid (10), rosmarinic (11), and rutin (12).Conclusion:
Compounds 1-9 are separated from I. lophanthoides var. gerardianus for the first time, and constituents of the water-soluble parts of I. lophanthoides var. gerardianus are studied systematically for the first time. Compounds 1, 6, and 11 exert antiproliferative effects on HepG2 cells.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Document type:
Article