Alkaloids from roots of Cocculus orbiculatus var. mollis / 中草药

ABSTRACT

Objective: To study the alkaloid compounds in the roots of Cocculus orbiculatus var. mollis. Methods: The compounds were isolated by silica gel chromatography, and their structures were established by spectroscopic methods. Results: A novel cocsolines-type bisbenzylisoquinoline alkaloid named orbiculatinine (1), along with three known compounds (+) 1, 2- dehydroapateline (2), trilobine (3), and isotrilobine (4), were isolated. Conclusion: Compound 1 is a new compound named orbiculatinine. Compounds 2-4 are isolated from this plant for the first time.