Analysis and strategy on pharmacokinetic/pharmacodynamic correlation of Chinese materia medica based on multi-components and multi-targets / 中草药

ABSTRACT

To analyze the correlation of pharmacokinetic/pharmacodynamic (PK/PD) of Chinese materia medica (CMM) based on the multi-components and multi-targets, through the example of demonstrative research, we brought forward some innovative strategies. The research requires to use a medicated serum in parallel at a pathologic state. The experiments included the determination of multi-components PK parameters, the establishment of serum dynamic fingerprints and multi-targets PD models, the research on PK/PD binding model, the selection of the analytic program, the representation of internal relations among the concentration, time, and effect in the effective component group, the analyses on the correlation between fingerprint and PD, the tracing of the rule of PD from the chemical fingerprints and metabolic fingerprints, and the construction of a spectrum which could represent the characterization of the correlation between the retention time and the effect and the characterization of dose-effect fingerprint spectrum of the correlation between peak area growth and effects. The multi-dimensional characteristics of fingerprint-pharmacophore fingerprints (feature effect peak and dose-effect fingerprint spectrum)-fingerprint spectrum of PK are integrated, processed, and edited and a multi-dimensional image of "active integration fingerprint" in the active component group was built. A new research method on the combination of the PK/PD of CMM was explored. Only by this way, we will really understand the interaction in active component group in vivo and clearly explain the material base which truly works.