Chemical constituents in ethyl acetate extract from aerial part of Gynura divaricata / 中草药

ABSTRACT

Objective: To study the chemical constituents of ethyl acetate fraction in 80% ethanol reflux extract from the aerial part of Gynura divaricata. Methods: Column chromatographic techniques were applied to isolate and purify the chemical constituents. The chemical structures of the constituents were elucidated on the basis of mass properties and NMR spectral data. Results: Fourteen compounds were isolated and their structures were determined spectroscopically as succinic acid (1), methyl succinate (2), ethyl succinate (3), ethyl methyl succinate (4), 4-hydroxybenzoic acid (5), salicylic acid (6), isovanillic acid (7), p-coumaric acid (8), esculetin (9), quercetin (10), kaempferol (11), isoquercitrin (12), astragalin (13), and rutin (14). Conclusion: Compounds 1-4 and 6-9 are isolated from this plant for the first time.