Effectiveness of Pharmacist-Participated Warfarin Anticoagulation Management on Patients with Pulmonary Embolism / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the effectiveness of pharmacist-participated warfarin anticoagulation management by patient education and medication consultation on patients with pulmonary embolism(PE). METHODS: A total of 204 PE patients were hospitalized in respiratory wards from March 2015 to April 2017 enrolled eventually. Evaluation endpoints including the percentage of INRs within the therapeutic range(TTR), the percentage of INRs within the expanded range(TER), INR recall intervals, bleeding events, emergency department visits and hospitalizations related to anticoagulation therapy. RESULTS: TTR and TER of intervention group were(70.89 ± 26.02)% and (87.71 ± 20.01)% respectively, which were both significantly higher than (47.79 ± 22.31)% and (71.23 ± 21.47)% in control group(P = 0.000). INR recall intervals were(27.48 ± 12.81) d versus(43.35 ± 13.65) d (P = 0.000). There were no significant differences between two groups in total bleeding events(41.96% vs 29.35%, P = 0.062), minor bleeding events(38.39% vs 27.17%, P = 0.091) and major bleeding events(3.57% vs 2.17%, P = 0.864). And a significantly decreased in emergency department visits of intervention group(9.82% vs 1.09%, P = 0.008), whereas no difference was observed in hospitalizations(8.04% vs 2.17%, P = 0.125). CONCLUSION: Clinical pharmacists participated in anticoagulation management of pulmonary embolism patients, which helped patients to monitor INRs more regularly, INR controlling better and decrease frequency of emergency department visits.