Risk Evaluation of Abnormal Liver Function Associated with LMWH in 76 PTE Patients of Our Hospital / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1456-1459, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-858615
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To explore the clinical regularities and risk factor of abnormal liver function associated with LMWH in pulmonary thromboembolism patients.METHODS:
Clinical date of pulmonary thromboembolism patients in use of LMWH was collected and analyzed from January 2008 to December 2016.RESULTS:
97 cases were enrolled. Of them, there were 76 cases were assessed as probable or possible. Single factor analysis showed the the levels of Scr (P=0.000), ALT (P=0.000), AST (P=0.000), γ-GGT (P=0.000), ALP (P=0.023), co-infection (P=0.024) and Ccr (P=0.026) had statistically significant difference. Multivariate analysis indicated that co-infection (OR=1.982, P=0.022) and high level of Scr (OR=1.045, P=0.000) were the independent risk factors of abnormal liver function associated with LMWH in PTE.CONCLUSION:
The incidence of abnormal liver function due to LMWH in PTE patients is high. With high level of Scr and/or co-infection patients are high-risk persons of abnormal liver function. It is necessary to dynamically evaluate the liver function during hospitalization. Symptomatic treatment can be significant if the liver function become abnormal.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2017
Document type:
Article